ADC TOXICITY ATLAS
Atlas
Payloads and Linkers
Payloads
Targets
Methods
← Payloads & linkers
Linker
HIPS-4AP
Non-cleavable
CNN(C)Cc1cc2ccccc2n1CCC(=O)N1CCC(N(CCOCCOCCC(=O)O)C(=O)CCC(=O)O)CC1
Physicochemistry
Properties
MW
603.72
Da
TPSA
153.88
Ų
xLogP
1.79
Formula
C30H45N5O8
Cleavage
Non-cleavable
Attachment
Genetic fusion
1 agent
ADCs built on this linker
Any-grade
Grade 3+
Agent · target
Ocular
Hepatic
Neutrop.
Thrombo.
Anemia
GI
ILD
Neuro.
TRPH-222
CD22
31
9.1
0%
severity
100%
0
Assessed · clear
true 0%
No data
never assessed