ADC TOXICITY ATLAS
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Linker

SPP (N-succinimidyl 4-(2-pyridyldithio)pentanoate)

Cleavable

[H]c1nc(SSC([H])(C([H])([H])[H])C([H])([H])C([H])([H])C(=O)ON2C(=O)C([H])([H])C([H])([H])C2=O)c([H])c([H])c1[H]
Physicochemistry

Properties

MW
340.426 Da
TPSA
76.57 Ų
xLogP
2.5978
Formula
C14H16N2O4S2
Cleavage
Cleavable
Attachment
Lysine
1 agent

ADCs built on this linker

Agent · target
Ocular
Hepatic
Neutrop.
Thrombo.
Anemia
GI
ILD
Neuro.
Lorvotuzumab mertansineNCAM1
4.7
16.5
30.9
17.5
0%severity100%
0
Assessed · clear
true 0%
No data
never assessed