ADC TOXICITY ATLAS
Atlas
Payloads and Linkers
Payloads
Targets
Methods
← Payloads & linkers
Linker
Dolasynthen cleavable ester linker (alanine ester; ADCdb LIN0OVBRO)
Cleavable
[H][C@@]12CCc3[nH]nnc3CC[C@]1([H])[C@@H]2COC(=O)NCCOCCOCCNC(=O)CCC(=O)NCC(=O)NCCOCCC(=O)NCCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H](COC(=O)NCCC(=O)N[C@@H](CCC(=O)N[C@@H](C)C(=O)O)C(=O)O)C(=O)NCCOCCOCCOCCOCCOCCOCCOCCOC
Physicochemistry
Properties
MW
1706.821
Da
TPSA
643.56
Ų
xLogP
-7.7695
Formula
C71H119N17O31
Cleavage
Cleavable
Attachment
Site-specific (enzymatic/non-natural AA)
1 agent
ADCs built on this linker
Any-grade
Grade 3+
Agent · target
Ocular
Hepatic
Neutrop.
Thrombo.
Anemia
GI
ILD
Neuro.
XMT-1660 (Emiltatug ledadotin)
VTCN1
0
38
0
0
29
0
0
0%
severity
100%
0
Assessed · clear
true 0%
No data
never assessed