ADC TOXICITY ATLAS
Payloads & linkers
Linker

Dolasynthen cleavable ester linker (alanine ester; ADCdb LIN0OVBRO)

Cleavable

[H][C@@]12CCc3[nH]nnc3CC[C@]1([H])[C@@H]2COC(=O)NCCOCCOCCNC(=O)CCC(=O)NCC(=O)NCCOCCC(=O)NCCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H](COC(=O)NCCC(=O)N[C@@H](CCC(=O)N[C@@H](C)C(=O)O)C(=O)O)C(=O)NCCOCCOCCOCCOCCOCCOCCOCCOC
Physicochemistry

Properties

MW
1706.821 Da
TPSA
643.56 Ų
xLogP
-7.7695
Formula
C71H119N17O31
Cleavage
Cleavable
Attachment
Site-specific (enzymatic/non-natural AA)
1 agent

ADCs built on this linker

Agent · target
Ocular
Hepatic
Neutrop.
Thrombo.
Anemia
GI
ILD
Neuro.
XMT-1660 (Emiltatug ledadotin)VTCN1
0
38
0
0
29
0
0
0%severity100%
0
Assessed · clear
true 0%
No data
never assessed