ADC TOXICITY ATLAS
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Linker

SPDB / sulfo-SPDB

Cleavable

[H]OS(=O)(=O)C([H])(C(=O)ON1C(=O)C([H])([H])C([H])([H])C1=O)C([H])([H])C([H])([H])SSc1nc([H])c([H])c([H])c1[H]
Physicochemistry

Properties

MW
406.463 Da
TPSA
130.94 Ų
xLogP
1.0756
Formula
C13H14N2O7S3
Cleavage
Cleavable
Attachment
Lysine
1 agent

ADCs built on this linker

Agent · target
Ocular
Hepatic
Neutrop.
Thrombo.
Anemia
GI
ILD
Neuro.
Mirvetuximab soravtansineFOLR1
59
57
22
17
18
29
10
36
0%severity100%
0
Assessed · clear
true 0%
No data
never assessed