ADC TOXICITY ATLAS
Atlas
Payloads and Linkers
Payloads
Targets
Methods
← Payloads & linkers
Linker
AcBut hydrazone + disulfide
Cleavable
CC(=O)c1ccc(OCCCC(N)=O)cc1
Physicochemistry
Properties
MW
221.256
Da
TPSA
69.39
Ų
xLogP
1.5335
Formula
C12H15NO3
Cleavage
Cleavable
Attachment
Lysine
3 agents
ADCs built on this linker
Any-grade
Grade 3+
Agent · target
Ocular
Hepatic
Neutrop.
Thrombo.
Anemia
GI
ILD
Neuro.
PF-06647263
EFNA4
8
12
4
28
16
60
8
Gemtuzumab ozogamicin
CD33
0
51
21
Inotuzumab ozogamicin
CD22
0
71
94
98
94
31
0%
severity
100%
0
Assessed · clear
true 0%
No data
never assessed