ADC TOXICITY ATLAS
AtlasPayloads and LinkersPayloadsTargetsMethods
← Payloads & linkers
Linker

LD19.10 (Mc-PEG8 hindered-disulfide linker)

Non-cleavable

NCNC(=O)CCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCC1C(=O)C=CC1=O
Physicochemistry

Properties

MW
575.656 Da
TPSA
182.97 Ų
xLogP
-1.2543
Formula
C26H45N3O11
Cleavage
Non-cleavable
Attachment
Site-specific (engineered Cys)
1 agent

ADCs built on this linker

Agent · target
Ocular
Hepatic
Neutrop.
Thrombo.
Anemia
GI
ILD
Neuro.
SC-011 / ABBV-011 (SC17, SEZ6, calicheamicin)SEZ6
0
35
40
15
45
0%severity100%
0
Assessed · clear
true 0%
No data
never assessed