ADC TOXICITY ATLAS
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Linker

NHS ester to Lys (IR700)

Cleavable

[H]OC([H])([H])C([H])([H])C([H])([H])OC(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)ON1C(=O)C([H])([H])C([H])([H])C1=O
Physicochemistry

Properties

MW
330.337 Da
TPSA
122.24 Ų
xLogP
0.2626
Formula
C14H22N2O7
Cleavage
Cleavable
Attachment
Lysine
1 agent

ADCs built on this linker

Agent · target
Ocular
Hepatic
Neutrop.
Thrombo.
Anemia
GI
ILD
Neuro.
Cetuximab saratolacanEGFR
0
16.7
23.3
0%severity100%
0
Assessed · clear
true 0%
No data
never assessed