ADC TOXICITY ATLAS
Atlas
Payloads and Linkers
Payloads
Targets
Methods
← Payloads & linkers
Linker
vc-seco-DUBA
Cleavable
CC(C)C(NC(=O)OCCOCCN1C(=O)C=CC1=O)C(=O)NC(CCCNC(N)=N)C(=O)Nc1ccc(COC(=O)N(C)CCN(CCOCCO)C(=O)O)cc1
Physicochemistry
Properties
MW
822.87
Da
TPSA
297.8
Ų
xLogP
-0.1919
Formula
C36H54N8O14
Cleavage
Cleavable
Attachment
Cysteine (interchain)
2 agents
ADCs built on this linker
Any-grade
Grade 3+
Agent · target
Ocular
Hepatic
Neutrop.
Thrombo.
Anemia
GI
ILD
Neuro.
Trastuzumab duocarmazine
ERBB2
78.1
5.5
15.8
5.5
10.3
18.5
7.6
Vobramitamab duocarmazine
CD276
19.8
5.8
25.6
14
26.7
30.2
2.3
4.7
0%
severity
100%
0
Assessed · clear
true 0%
No data
never assessed