ADC TOXICITY ATLAS
AtlasPayloads and LinkersPayloadsTargetsMethods
← Payloads & linkers
Linker

VA dipeptide + engineered Cys (EC-mAb)

Cleavable

[H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C(=O)C([H])=C([H])C1=O)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
Physicochemistry

Properties

MW
381.429 Da
TPSA
132.88 Ų
xLogP
0.2019
Formula
C18H27N3O6
Cleavage
Cleavable
Attachment
Site-specific (engineered Cys)
2 agents

ADCs built on this linker

Agent · target
Ocular
Hepatic
Neutrop.
Thrombo.
Anemia
GI
ILD
Neuro.
Serclutamab talirine (ABBV-321, EGFR, PBD/SGD-1882)EGFR
7
21
18
5
18
2
Vadastuximab talirineCD33
0
5
18
44
38
34
0%severity100%
0
Assessed · clear
true 0%
No data
never assessed