ADC TOXICITY ATLAS
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Linker

GGFG tetrapeptide

Cleavable

[H]OC(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)C([H])([H])N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C(=O)C([H])=C([H])C1=O)C([H])([H])c1c([H])c([H])c([H])c([H])c1[H]
Physicochemistry

Properties

MW
529.55 Da
TPSA
191.08 Ų
xLogP
-1.3675
Formula
C25H31N5O8
Cleavage
Cleavable
Attachment
Cysteine (interchain)
4 agents

ADCs built on this linker

Agent · target
Ocular
Hepatic
Neutrop.
Thrombo.
Anemia
GI
ILD
Neuro.
Datopotamab deruxtecanTACSTD2
38
24
30
35
56
2.4
Trastuzumab deruxtecanERBB2
11
67
70
52
64
76
11
13
Trastuzumab rezetecanERBB2
3.3
42.9
79.4
42.9
76.2
79.4
11.6
Patritumab deruxtecanERBB3
2.7
16.9
37.3
43.6
32.9
65.3
5.3
0%severity100%
0
Assessed · clear
true 0%
No data
never assessed