ADC TOXICITY ATLAS
Atlas
Payloads and Linkers
Payloads
Targets
Methods
← Payloads & linkers
Linker
SMCC
Non-cleavable
[H]C1=C([H])C(=O)N(C([H])([H])C2([H])C([H])([H])C([H])([H])C([H])(C(=O)ON3C(=O)C([H])([H])C([H])([H])C3=O)C([H])([H])C2([H])[H])C1=O
Physicochemistry
Properties
MW
334.328
Da
TPSA
101.06
Ų
xLogP
0.325
Formula
C16H18N2O6
Cleavage
Non-cleavable
Attachment
Lysine
2 agents
ADCs built on this linker
Any-grade
Grade 3+
Agent · target
Ocular
Hepatic
Neutrop.
Thrombo.
Anemia
GI
ILD
Neuro.
AVID-100
EGFR
8
20
24
4
32
Trastuzumab emtansine
ERBB2
5
98
39
83
60
40
1.2
21
0%
severity
100%
0
Assessed · clear
true 0%
No data
never assessed