ADC TOXICITY ATLAS
Atlas
Payloads and Linkers
Payloads
Targets
Methods
← Payloads & linkers
Linker
MC-vc-PAB + K-Lock (site-specific)
Cleavable
CC(C)C(NC(=O)CCC(=O)N1CCC(C(=O)O)CC1)C(=O)NC(CCCNC(N)=N)C(=O)Nc1ccc(CO)cc1
Physicochemistry
Properties
MW
590.678
Da
TPSA
220.26
Ų
xLogP
0.2949
Formula
C28H42N6O8
Cleavage
Cleavable
Attachment
Site-specific (engineered Cys)
1 agent
ADCs built on this linker
Any-grade
Grade 3+
Agent · target
Ocular
Hepatic
Neutrop.
Thrombo.
Anemia
GI
ILD
Neuro.
A166
ERBB2
100
18.5
10.8
4.6
23.5
10.8
3.1
53.1
0%
severity
100%
0
Assessed · clear
true 0%
No data
never assessed