ADC TOXICITY ATLAS
Atlas
Payloads and Linkers
Payloads
Targets
Methods
← Payloads & linkers
Linker
Mal-glucuronide-PABC (beta-glucuronide-exatecan)
Cleavable
O=C(CCN1C(=O)C=CC1=O)NCC(=O)Nc1cc(CO)ccc1O[C@@H]1O[C@H](C(=O)O)[C@@H](O)[C@H](O)[C@@H]1O
Physicochemistry
Properties
MW
523.451
Da
TPSA
232.26
Ų
xLogP
-3.1803
Formula
C22H25N3O12
Cleavage
Cleavable
Attachment
Cysteine (interchain)
1 agent
ADCs built on this linker
Any-grade
Grade 3+
Agent · target
Ocular
Hepatic
Neutrop.
Thrombo.
Anemia
GI
ILD
Neuro.
M-9140
CEACAM5
0
12.5
42.5
35
57.5
12.5
0%
severity
100%
0
Assessed · clear
true 0%
No data
never assessed